In addition, they play a major role in cardiac cachexia and exacerbate prognosis.8 Many studies have been con-ducted on the relationship between CHD and cytokine levels in cyanotic and acyanotic individuals.9 In patients with CHD, ghrelin, leptin, TNF-a, and interleukins are thought to have a regulating role in feeding, growth, weight, and energy.10 CHD also is a cause of malnutrition and growth retardation in children.11 As a biomarker, IL-18 is introduced for early diagnosis and prognosis in patients with acute kidney injury in the intensive care unit. The gene discussed is TNF; the disease is coronary artery disorder.