Common low-penetrance mostly non-coding variants in TNFAIP3 have been associated with many autoimmune diseases including systemic lupus erythematosus (SLE) (49–51), RA (52), psoriasis (53), type 1 diabetes (54), celiac disease (55), coronary artery disease (56), inflammatory bowel disease (57), and more recently with protection to allergy and asthma (58, 59). Here, TNFAIP3 is linked to rheumatoid arthritis.