TNFAIP3 and autoimmune disease: Common low-penetrance mostly non-coding variants in TNFAIP3 have been associated with many autoimmune diseases including systemic lupus erythematosus (SLE) (49–51), RA (52), psoriasis (53), type 1 diabetes (54), celiac disease (55), coronary artery disease (56), inflammatory bowel disease (57), and more recently with protection to allergy and asthma (58, 59).