Tamoxifen-induced Otulin ablation in murine immune cells (CreERT2-OtulinLacZ/flox chimeras) resembles the phenotype described in patients with otulipenia/ORAS including responsiveness to therapy with TNF inhibitors (18). The gene discussed is OTULIN; the disease is autoinflammation, panniculitis, and dermatosis syndrome, autosomal recessive.