Acute stress exposure was also shown to induce an increase in prefrontal CRHR1 expression in MS animals (compared to a decrease in controls), but not a reduction in amygdala CRHR1 expression (as seen in controls), and to induce significant increased amygdalar CRHR2 and hippocampal CRHR1 expression in MS animals specifically (O'Malley et al., 2011). The gene discussed is CRHR1; the disease is myeloid sarcoma.