Despite the fact that neonatal stress typically induces an anxiogenic phenotype (Huot et al., 2002; Kalinichev et al., 2002; Daniels et al., 2004; Rees et al., 2006; Aisa et al., 2007; Trujillo et al., 2016), this apparent decrease in GR expression was associated with reduced anxiety of the ELS animals compared to controls, which was normalized by lentiviral-mediated restoration of GR levels (Arnett et al., 2015). This evidence concerns the gene NR3C1 and Anxiety.