To compare with the Shank3 interactomes, we selected three established disease-associated gene lists; intellectual disability-associated FMRP (Fragile X mental retardation protein) target genes (Darnell et al., 2011), ASD-associated SFARI (Simons Foundation Autism Research Initiative) genes4, and psychiatric disorder-associated PsyGeNET (Psychiatric disorders Gene association NETwork) genes (Gutierrez-Sacristan et al., 2015). The gene discussed is SHANK3; the disease is psychiatric disorder.