While hypo-function of Nrg1 is linked to schizophrenia-like behaviors in BACE1-null mice, enhanced expression of either BACE1-cleaved Nrg1-ntf fragment or of full-length Nrg1 surprisingly also induces schizophrenia-like behaviors (Kato et al., 2010; Luo et al., 2013; Yin et al., 2013; Agarwal et al., 2014). This evidence concerns the gene BACE1 and schizophrenia.