In relation to the conventional pathways in T2DM, pathways of insulin secretion in pancreas showed similar gene expression alterations between zebrafish and human (Fig. 5a, b), while pathways of insulin resistance in liver (Fig. 5c, d) showed species similarity only in the central cascade, IL6 – STAT3, a known pathway in human T2DM54. This evidence concerns the gene STAT3 and type 2 diabetes mellitus.