In relation to the conventional pathways in T2DM, pathways of insulin secretion in pancreas showed similar gene expression alterations between zebrafish and human (Fig. 5a, b), while pathways of insulin resistance in liver (Fig. 5c, d) showed species similarity only in the central cascade, IL6 – STAT3, a known pathway in human T2DM54. The gene discussed is IL6; the disease is type 2 diabetes mellitus.