Whereas the recent article by Lu CX et al. does suggest a direct link between the p.L47P HAND2 variant and TOF66, we suggest that our p.G202V variant doesn’t contribute to all four phenotypes observed in Tetralogy of Fallot, but rather contribute to at least one of them probably the one pertaining to the overriding aorta, since the same variant is also found in both patients with CoA and aortic stenosis (Supplementary Table 1). Here, HAND2 is linked to Tetralogy of Fallot.