Multivariate logistic regression analysis revealed that TPH (OR = 0.905; 95% confidence interval [CI], 0.863–0.949; P = 0.000), tumor size (OR = 1.176; 95% CI, 1.049–1.318; P = 0.005), and WIS (OR = 0.270; 95%CI, 0.083–0.882; P = 0.030) differed significantly between the ECE and non-ECE groups. The gene discussed is TPH1; the disease is neoplasm.