Two recently discovered ALS-associated genes, chromosome 21 open reading frame 2 (C21orf2) (van Rheenen et al., 2016) and NIMA-related kinase 1 (NEK1) (Kenna et al., 2016) are involved in cilia formation, but also interact with each other in a complex involved in DNA repair. Here, CFAP410 is linked to amyotrophic lateral sclerosis.