TARDBP and amyotrophic lateral sclerosis: The most common ALS disease-causing gene mutations are found in: C9orf72 (which encodes chromosome 9 open reading frame 72), it is responsible for 10-15% of all ALS and contains a hexa nucleotide repeat expansion; SOD1 (superoxide dismutase 1), responsible for 2% of ALS; TARDBP (TAR DNA-binding protein 43), responsible for 0.9% of ALS; and FUS (fused in sarcoma), responsible for 0.7% of ALS (Al-Chalabi et al., 2017; Renton et al., 2014).