An in-depth discussion of all recent ALS rodent models is beyond the scope of this article, and we refer readers to recent reviews on rodent models for ALS-associated mutations in SOD1, TARDBP, FUS and C9orf72 for more information (Gendron and Petrucelli, 2011; Nolan et al., 2016; Philips and Rothstein, 2015; Turner and Talbot, 2008). The gene discussed is FUS; the disease is amyotrophic lateral sclerosis.