TARDBP and amyotrophic lateral sclerosis: Interestingly, modifying the expression levels of the ALS risk-enhancing genes UNC13A (van Es et al., 2009) and SARM1 (van Rheenen et al., 2016) also modified neurodegeneration in C. elegans models of mutant TDP-43 and FUS (Veriepe et al., 2015).