Fly models overexpressing mutant human transgenes for ALS linked to mutations in SOD1 (Watson et al., 2008), TARDBP (Estes et al., 2011; Feiguin et al., 2009; Vanden Broeck et al., 2013), FUS (Chen et al., 2011; Lanson et al., 2011), C9orf72 (Mizielinska et al., 2014; Xu et al., 2013), ALS2 (Takayama et al., 2014), VAPB (Ratnaparkhi et al., 2008; Tsuda et al., 2008), VCP (Johnson et al., 2015) and SETX (Mushtaq et al., 2016) exist. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.