Moreover, bioinformatic analysis has revealed two single SNPs in the gene encoding the only endogenous inhibitor of calpain, the calpastatin gene (CAST), which might predispose Caucasian individuals with European ancestry to idiopathic PD (Allen and Satten, 2009, 2010; Dauer and Przedborski, 2003). This evidence concerns the gene CAST and Parkinson disease.