Another example is based on the finding that miR-155 is increased in spinal cord from ALS patients and in an ALS mouse model with a mutation in SOD1. A locked nucleic acid (modified RNA nucleotide) anti-miR-155 reduces miR-155 levels in this mouse (Butovsky et al., 2015; Figueroa-Romero et al., 2016), thereby increasing survival and restoring the abnormal microglia and monocyte inflammatory signature (Butovsky et al., 2015). Here, SOD1 is linked to amyotrophic lateral sclerosis.