Using lysates from NSC-34 motor neuron cells overexpressing ALS-causing mutations in TARDBP and FUS in a cell-free dicing activity assay, Dicer function was shown to be altered resulting in an inhibition of miRNA biogenesis (Emde et al., 2015) (see poster panel C). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.