Microarray profiling followed by gene set enrichment analysis (GSEA) confirmed that mouse and human intestinal stem cell gene expression signatures were upregulated in LGR5‐EGFP+, whereas the differentiation program of colon epithelium was enriched in LGR5‐EGFP− CRC cells (Fig 2F). This evidence concerns the gene LGR5 and colorectal carcinoma.