Colorectal cancer stem cells had been previously isolated from patient samples using distinct surface markers including CD44, CD133, or EPHB2, which enrich in populations of tumor‐initiating cells (O'Brien et al, 2007; Dalerba et al, 2007; Ricci‐Vitiani et al, 2007; Merlos‐Suarez et al, 2011). Here, PROM1 is linked to colorectal cancer.