LGR5 and neoplasm: Tumors generated by LGR5‐EGFP+ cells were populated with stem‐like (EGFP+/KRT20−) and differentiated‐like (EGFP−/KRT20+) tumor cells in similar proportions than the primary xenografts from which they were purified (Fig 2K) thus implying that LGR5‐expressing CRC cells undergo self‐renewal and differentiation during tumor expansion.