INTERHEART identified 9 potentially modifiable risk factors (PMRFs) that collectively account for ≥90% of the population attributable risk for acute myocardial infarction (MI) worldwide: smoking, history of hypertension, diabetes mellitus, abdominal obesity, psychosocial factors, daily consumption of fruits and vegetables, regular alcohol consumption, regular physical activity, and a raised apolipoprotein (Apo)B/ApoA1 ratio. This evidence concerns the gene APOA1 and myocardial infarction.