ICAM-1 expression on vascular endothelium is upregulated in experimental models of cerebral malaria (P. berghei ANKA) and infections of mice deficient in ICAM-1 expression (icam1−/−) show improved survival [20, 21] and reduced sequestration in the alveolar capillaries of the lung [21]. The gene discussed is ICAM1; the disease is cerebral malaria.