He proposed then a 5–10% risk of recurrence of TRPS1 for healthy parents with an affected child, in all patients with presumed de novo mutations, based on the known recurrence risk in other dominant conditions with demonstrated germinal mosaicism, such as Cornelia de Lange syndrome and Rubinstein-Taybi syndrome [35]. The gene discussed is TRPS1; the disease is Rubinstein-Taybi syndrome.