Dembinski et al. [84] and Ceranowicz et al. [85] also demonstrated that administration of this peptide inhibits the development of I/R-induced pancreatitis and CIP, and this effect is mediated by its influence on the release of growth hormone (GH) and insulin-like growth factor (IGF)-1. This evidence concerns the gene IGF1 and hereditary sensory and autonomic neuropathy.