Other studies have also revealed a correlation between body fat mass and intensity of total oxidative status and also between insulin resistance indicators, obesity markers and atherogenic index [51,52].Positive correlations of HOMA-IR index with both waist circumference (p < 0.001, r = +0.29), the proinsulin/adiponectin ratio (p < 0.001, r = +0.45) and triglyceride /HDLc ratio (p < 0.001, r = +0.32) are obvious arguments supporting the significant relationship between insulin resistance, pancreatic beta cells dysfunction and hypertrophic and “aggressive” fat cells. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.