INS and Insulin resistance: The excess glucose determines an enhancement in the production of free radicals which inhibit the activity of GLUT4 (intracellular glucose transporter sensitive to insulin), amplify the oxidative stress (by increasing the oxidant status and the respiratory burst, decreasing the antioxidant capacity exerted by superoxide dismutase, glutathione peroxidase, glutathione or both mechanisms) and enhance insulin resistance [12,13].