Also, a negative correlation was found between adiponectin and triglycerides/HDLc ratio (p < 0.001, r = −0.27), supporting the hypothesis that the type (particularly abdominal) and the degree of obesity is accompanied by increasing leptin and decreased adiponectin levels, both adipokines being secreted by the adipose tissue. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.