Other studies have also revealed a correlation between body fat mass and intensity of total oxidative status and also between insulin resistance indicators, obesity markers and atherogenic index [51,52].Positive correlations of HOMA-IR index with both waist circumference (p < 0.001, r = +0.29), the proinsulin/adiponectin ratio (p < 0.001, r = +0.45) and triglyceride /HDLc ratio (p < 0.001, r = +0.32) are obvious arguments supporting the significant relationship between insulin resistance, pancreatic beta cells dysfunction and hypertrophic and “aggressive” fat cells. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.