LGALS3 and hydrops fetalis: In HF, Meijers et al. [26] demonstrated unchanged urinary Gal-3 excretion despite elevated plasma Gal-3 concentrations, and a 40% lower renal Gal-3 clearance, averaging only about 4 mL/min in the healthy controls, which is indicative of abnormal renal handling of Gal-3 in HF beyond eGFR depression.