Out of 80 subjects enrolled, 30 patients (38%)—in accordance with a previous report based on the same method of Gal-3 assay in 101 AS patients undergoing transcatheter aortic valve implantation (TAVI) [21]—had a Gal-3 level higher than the cut-off value of 17.8 ng/mL, previously proposed for risk stratification in established HF [5,11]. Here, LGALS3 is linked to aortic stenosis.