Therefore, it can be hypothesized that the eGFR–Gal-3 relationship obscured expected associations of Gal-3 with other parameters also in our AS patients, in whom Gal-3 was unrelated to indices of stenosis severity, EF, LV mass and symptomatic status, like in the previously cited reports [20,21]. This evidence concerns the gene LGALS3 and aortic stenosis.