LGALS3 and aortic stenosis: Baldenhofer et al. [21] reported a highly significant negative correlation of Gal-3 with eGFR in subjects with severe AS referred for TAVI., Additionally, in 583 patients with at least mild AS (out of whom 53% presented severe AS), Arangalage et al. [20] demonstrated that depressed creatinine clearance and increased age were the strongest determinants of plasma Gal-3.