Heat shock induces the release of exosomes with increased amounts of HSPA1A, which promote antitumor immune responses, with increased expression of major histocompatibility complex (MHC) class II in colon (CT26) and melanoma (B16) models [159], migration and reactivity of natural killer (NK) cells metastatic pancreatic adenocarcinoma Colo357 cells [160], thus inhibiting tumor growth and prolonging survival of tumor-bearing mice (Lewis lung carcinoma cell line and B16 melanoma cell line) [161]. Here, HSPA1A is linked to neoplasm.