Dentelli et al. reported that visceral (intra-abdominal) preadipocytes isolated from patients with type 2 diabetes were more numerous than those from control subjects, and that they exist in a more de-differentiated versus a committed state, based on a higher expression of Oct4 and Nanog (indicators of stemness) [19]. This evidence concerns the gene POU5F1 and type 2 diabetes mellitus.