ME3 and breast cancer: Remarkably, upon comparison of clinical DNA methylation data from the TCGA with WA induced DNA hypermethylation of CpG motifs in PLAU, ADAM8, TNFSF12, ME3 and GSTM1 genes, we identified a strong correlation with the HER2/PR/ESR status in invasive BC patients (Table 1, Figure 7A).