Remarkably, upon comparison of clinical DNA methylation data from the TCGA with WA induced DNA hypermethylation of CpG motifs in PLAU, ADAM8, TNFSF12, ME3 and GSTM1 genes, we identified a strong correlation with the HER2/PR/ESR status in invasive BC patients (Table 1, Figure 7A). This evidence concerns the gene ESR1 and breast cancer.