BCL2L11 and non-small cell lung carcinoma: It was therefore hypothesised that the BIM deletion would have an impact on the sensitivity of EGFR-addicted tumors to EGFR-TKIs, and indeed the polymorphism was associated with shorter progression-free survival (PFS) in a retrospective EGFR-TKI-treated NSCLC cohort from Singapore and Japan [22].