Specifically, the levels of circulating MALAT1 (Figure 4D), AFAP1-AS1 (Figure 4E) and AL359062 (Figure 4F) of NPC patients of T3-4 subgroups, N2-3 subgroups and M1 subgroup were remarkably higher than that of T1-2 subgroups, N0-1 subgroups and M0 subgroup (all with p < 0.001), respectively. The gene discussed is MALAT1; the disease is nasopharyngeal carcinoma.