Some lncRNAs, such as HOTAIR [31, 33], H19 [34], NEAT1 [35], HNF1A-AS [36], ANRIL [32], are reported to be oncogenic molecules in NPC, while GAS [37] and MEG3 [38] lncRNAs act as tumor suppressors. The gene discussed is HOTAIR; the disease is nasopharyngeal carcinoma.