UHRF1 and retinoblastoma: Therefore, our results suggest a possibility that high UHRF1 expression may not decrease global DNA methylation in mouse retinoblastoma and global DNA hypomethylation may not be an early mechanism driving retinoblastoma development, although this possibility needs to be further validated because the specific cell type from which retinoblastoma arises could not be analysed in parallel as the normal cell counterpart in this study.