Based on the results, both RNAi knockdown and the inhibitor blockade of the GLUT1 resulted in decreased cytotoxicity and decreased intracellular platinum accumulation in HT29 cell line, suggesting that the sugar conjugates was transported mainly via GLUT1 and all three sugars as glycoconjugation motif have similar effect to enable the platinum(II) complexes as substrate for GLUT1 mediated tumor targeting. This evidence concerns the gene SLC2A1 and neoplasm.