This non-canonical pathway is the molecular basis for anti-CD40–induced repolarization of TAMs from a tumor-promoting M2 to a suppressive M1-like phenotype with upregulation of IL12, TNFα and INF-γ in KPC mice which spontaneously develop pancreatic ductal adenocarcinoma [83]. The gene discussed is TNF; the disease is pancreatic ductal adenocarcinoma.