TGFB1 and neoplasm: They release limited amounts of nitric oxide by expressing both inducible nitric oxide synthase (iNOS) and arginase 1 and induce the differentiation of Tregs that maintain an immunosuppressive environment by secreting TGFβ and interleukin 10 (IL10) and competitively binding and neutralizing the anti-tumor cytokines such as IL2, IL7, IL12 and IL15 [17, 18].