In addition to TGFβ, CAFs release stromal cell-derived factor 1 (SDF-1/CXCL12), which recruits endothelial progenitor cells to the tumor site to facilitate angiogenesis and directly promote tumor growth via binding to its cognate receptor, CXCR4, expressed by cancer cells [3]. This evidence concerns the gene TGFB1 and neoplasm.