Because recruitment of TAMs to target vessels to induce vascular permeability requires CCL2 and colony-stimulating factor 1 (CSF1) synthesized by tumor cells to target receptor CCR2 and CSF1R on TAMs [4, 49], inhibition of CCR2 or CSF1R signaling reduces tumor growth and metastasis [50–53]. This evidence concerns the gene CSF1 and neoplasm.