TGFB1 and neoplasm: M2-like TAMs either produce immunosuppressive factors such as IL10 and TGFβ to inhibit CD4+ and CD8+ T cell effector function or secret chemoattractant such as CCL3, CCL4, CCL5, CCL18 and CCL22 to recruit factors associated with Tregs by targeting chemokine receptors CCR4, CCR5, CCR6 and CCR10 to TME to suppress the anti-tumor response [8].