Wu et al performed a study that demonstrated that five lncRNAs are significantly dysregulated in the serum of RCC patients-lncRNAs (LET, PVT1, PANDAR, PTENP1, and linc00963)- this 5 lncRNAs serum signature may obtain a preferable sensitivity and specificity for distinguishing ccRCC patients from normal individuals [76]. This evidence concerns the gene PVT1 and nonpapillary renal cell carcinoma.