Immunohistochemical stainings of cyclin E, MCM2, VEGF, CDC6 and BCL2 were performed in tumor tissues, and the staining intensities of cyclin E, MCM2, CDC6 and BCL2 were decreased in the GBK treatment group in xenograft-tumor mice compared to the control group (Figure 7G). Here, MCM2 is linked to neoplasm.