Moreover, the blood sugar level (p < 0.01; Figure 1B) and the insulin levels of brain and serum (p < 0.05; Figure 1E and 1F) in ob/ob mice and APP/PS1-ob/ob mice were remarkably higher than those in the wild type (WT) and APP/PS1 mice, suggesting that APP/PS1-ob/ob mice also showed severe symptoms of hyperglycemia and hyperinsulinemia at 6 months of age. This evidence concerns the gene APP and hyperinsulinism.