In contrast, expression levels of enzymes involved in downstream metabolism of isocitrate, including IDH1, IDH2 and IDH3A, α-KGDH, succinate dehydrogenase (SDHB), fumarate hydratase (FH) and malate dehydrogenase (MDH2), were remarkably lower in IDH1MUT glioma versus IDH1WT glioma. The gene discussed is MDH2; the disease is central nervous system cancer.