In addition to glioma, IDH1/2 mutations (IDH1/2MUT) occur in substantial percentages in various other tumor types, such as acute myeloid leukemia (20–40%), chondrosarcoma (60%), intrahepatic cholangiocarcinoma (20%) and melanoma (5–10%) [6]. This evidence concerns the gene IDH1 and intrahepatic cholangiocarcinoma.