Mashimo et al. did not stratify their glioblastoma cohort based on IDH1MUT status but demonstrated higher expression of ACSS2 in glioblastoma than in grade II and III glioma and high ACSS2 expression in LGG patients with poor survival as opposed to low ACSS2 expression in LGG patients with prolonged survival. The gene discussed is ACSS2; the disease is central nervous system cancer.