BCAT1 and glioma: Our results support the findings of previous studies that demonstrated increased conversion of glutamate to α-KG by GLUD [45, 56] and reduced conversion of α-KG to glutamate by BCAT1 in IDH1MUT glioma, which is in line with promoter methylation of BCAT1 in IDH1MUT glioma [29, 57].