Herein, the functions of JMJD2A promotion of liver cancer stem cell growth is explained by results from two parallel sets of experiments: (1) JMJD2A is overexpressed and associated with miR372, P21(WAF1/Cip1), Pim1 in human liver cancer tissues; (2) JMJD2A accelerates malignant progression of liver cancer cells in vitro and in vivo. This evidence concerns the gene CDKN1A and liver cancer.