The first report on the use of a GnRH agonist as ovulation trigger in the context of OHSS prevention came from the Rambam Health Care Campus (Rambam), Haifa, Israel and appeared in 1988 as an abstract.3 Soon after, a full paper was published, underscoring the concept that a bolus of GnRH agonist is able to trigger an adequate mid-cycle LH/FSH surge, resulting in oocyte maturation and pregnancy. This evidence concerns the gene PLOD1 and ovarian hyperstimulation syndrome.