In addition, the inhibitory effect of TAS2Rs on invasion/migration was demonstrated in relation to suppression of the enzymatic activity and expression of MMPs, including the transcriptional activity of HIF-1α and its downstream genes, VEGF and GLUT1. Taken together, these novel insights into the molecular mechanisms of TAS2Rs suggest that this class of GPCRs represents a promising cancer therapeutic target to affect the cancer stemness and invasive phenotype of NB cells. This evidence concerns the gene VEGFA and cancer.