AKT1 and schizophrenia: Notably, similar cytoarchitectural changes have been reported in postmortem brain of patients with schizophrenia [76–80] and in conjunction with evidence for genetic association to biological pathways that regulate axonal, dendritic, and postsynaptic development [6], suggest that at least some neuropathological changes may be genetically determined, neurodevelopmental in origin, and potentially related to alterations in AKT signaling.