Metastasis involves a complex cascade of events, beginning with the formation of a tumor blood supply, followed by escape of tumor cells from the primary tumor mass, invasion and migration through the extracellular matrix/basal lamina utilizing heparanase and matrix metalloproteinase enzymes, entry into the tumor blood supply, and later extravasation at a distant site to form secondary tumor foci [25]. Here, HPSE is linked to neoplasm.