Analysis of high throughput datasets (mostly from ENCODE consortium [9,10]) depicting DNAse footprinting (DNase 1 hypersentitive sites, DHSs), chromatin immuno-precipitations coupled to deep sequencing (ChIP-seq) and targeting specific histone modifications or RNA polymerase II (RNA Pol II), CCCTC-binding factor (CTCF) and various transcription factors (TFs) interacting with NRAMP1 locus, in both acute myeloid leukemia (AML) cell lines and primary monocytes, allowed us to delineate a ~40 kb regulatory domain insulated by CTCF sites [11]. Here, SLC11A1 is linked to acute myeloid leukemia.