It has been shown that p53 regulates glucose uptake and glycolysis reducing the expression of glucose transporters (GLUT1, GLUT3, and GLUT4), phosphoglycerate mutase (PGM), and fructose-2,6-bisphosphate levels [78,79]; moreover, it induces the transcription of TIGAR and GLS2 target genes [65,80,81] in both tumor and normal cell lines. The gene discussed is GLS2; the disease is neoplasm.