WWTR1 and cancer: Down-regulation of the core kinase cassette components or activators of the Hippo pathway results in uncontrolled tissue overgrowth; moreover, YAP/TAZ overexpression induces cell proliferation, inflammation, acquisition of cancer stem cell features, EMT (forming metastases), inhibition of senescence, suppressed anoikis, reduced apoptosis, and drug resistance [9,16,18,213,216,230,242,243].