Since overexpression of TCF7L1* had little effect on tumor size, OIS, and migration while TCF7L1ΔG still affected OIS and SCC cell migration, albeit significantly less than the full length and TCF7L1ΔN (Figures 5D, 6D and 7B), we decided to focus on the genes that were altered by TCF7L1 and TCF7L1ΔN but not by TCF7L1*. The gene discussed is TCF7L1; the disease is neoplasm.