We hypothesized that TCF7L1 overexpression may help tumor cells overcome oncogene-induced senescence, which is a phenomenon observed both in vitro (Serrano et al., 1997) and in vivo (Braig et al., 2005; Chen et al., 2005; Collado et al., 2005; Lazzerini Denchi et al., 2005; Michaloglou et al., 2005). Here, TCF7L1 is linked to neoplasm.