IL6R and obesity due to melanocortin 4 receptor deficiency: We generated T cell-specific IL-6Rα knockout mice (IL-6RαT-KO) and subjected them to diet-induced obesity via exposure to a high-fat diet (HFD, 60% Kcal fat) for 8 and 16 weeks, at which points their metabolic phenotype was characterized and the concurrent inflammatory state of liver and epididymal white adipose tissue (EWAT) was assessed.