Significantly, several of the common proteins were previously implicated in miRNA biogenesis and/or regulation, including the heat shock cognate 70 protein5, the hnRNP proteins, hnRNP A1 (refs 17, 19) and hnRNP A2/B1 (ref. 28), the RNA helicase DDX17 (ref. 4), poly adenosine diphosphate ribose (ADP-ribose) polymerase 1 (PARP)29, and the RNA-BPs fused in sarcoma/translocated in liposarcoma (FUS/TLS; Fig. 4a and Supplementary Fig. 4a). The gene discussed is PARP1; the disease is sarcoma.