Although only two patients were reported, it made sense to CAR-T cell therapy development as it not only provided an effective approach to the management of sCRS by incorporating tocilizumab (a recombinant humanized monoclonal antibody against interleukin-6 receptor (IL-6R)) without compromising efficacy, but also highlighted the significant threat to a successful CAR regimen, namely, tumor antigen loss escape. Here, IL6R is linked to neoplasm.