Unfortunately, the first patient with metastatic HER2+ colon cancer who received 1010 T cells (79% CAR+) following conditioning chemotherapy developed rapid respiratory distress within 15 min after cell infusion and ultimately died of multiple organ failure as a result of reactivity against lung epithelial cell expression of low levels of HER2 (Morgan et al., 2010). This evidence concerns the gene ERBB2 and colonic neoplasm.