EGFR and neoplasm: Of note, immunohistochemistry (IHC) examination of biopsy tumor tissues from patients achieving either PR or SD illustrated that anti-EGFR CAR-T cells could traffic to tumor sites and infiltrate the tumor tissues and elicit EGFR-specific cytotoxicity even at 3.5 months post-cell infusion, implying that anti-EGFR CAR-T cells could persist and remain functional in an immunosuppression microenvironment.