ERBB2 and osteosarcoma: Updated results of this trial in the first 19 patients with HER2-positive sarcoma (including 16 osteosarcomas) further confirmed that anti-HER2 CAR-T cell treatment was safe and feasible as no dose-limiting toxicity (DLT) was observed even in the highest dose level of 1 × 108 CAR+ T cells/m2 (Ahmed et al., 2015).