CD19 and neoplasm: Of note, due to the concern that the pre-emptive CRS treatment could impair the anti-tumor efficacy of the infused CAR-T cells, Ruella et al. added kinase inhibitor ibrutinib to anti-CD19 CAR-T cells in an effort to prevent CRS, and proved the feasibility of this strategy in an NOD/SCID/gamma-chain-deficient (NSG) mice model.