Building on their previous experience in 3 patients with glioblastoma that multiple intracranial infusions of first generation CAR-T cells targeting IL13Rα2 was well-tolerated (Brown et al., 2015), the investigators at City of Hope National Medical Center (City of Hope; USA) conducted a trial (NCT02208362) to evaluate a IL13Rα2-specific BBζ CAR (IL13 BBζ-CAR) without lymphodepleting chemotherapy in GBM and reported their clinical experience in one patient with recurrent multifocal GBM (Brown et al., 2016). The gene discussed is IL13; the disease is glioblastoma.