MSLN and ovarian carcinoma: In light of the aforementioned safety profile of anti-MSLN CAR-T cells, researchers opened a trial to test anti-MSLN CAR-T cells transduced with lentivirus for PDAC, epithelial ovarian cancer, and malignant epithelial pleural mesothelioma (NCT02159716), and reported the early results of this trial at AACR 2015 (Tanyi et al., 2015).