Two single nucleotide polymorphisms of rs4237 and rs2501431 in CNR2 (Cannabinoid Receptor 2) gene may result in postmenopausal osteoporosis in Han Chinese women [11]. Mettl21c (methyltransferase-like 21C) may play bone-muscle pleiotropic roles through the regulation of the NF-κB signaling pathway [12]. Here, CNR2 is linked to postmenopausal osteoporosis.