NFIC and osteoporosis: The former researches using the data of GSE35959 demonstrated that nuclear factor I-C (NFI-C) regulated osteoblast differentiation [14], mechanical stimulation affected genes expression associated with osteogenic differentiation of BMSCs through the regulation of HDAC1 (Histone Deacetylase 1) [15], or the transcriptional profile of MSC populations in primary osteoporosis showed overexpression of osteogenic inhibitors [16].