In this study, we investigated the UVB-protection activity of clinically used herbal medicines on skin disorder AD. P. cicadae showed significant skin protection effects, including inhibition of expression of IL-6 and MMPs; downregulation of the irradiation-induced p53, AP-1, and NF-κB; and upregulation of the amount of Nrf-2. The gene discussed is JUN; the disease is Alzheimer disease.