High expression of EphA3 was associated with differentiated histology (p < 0.001), depth of tumor (p = 0.002), lymph node metastasis (p = 0.001), stage (p < 0.001), recurrence (p = 0.024), especially liver recurrence (p = 0.024) and HER2 expression (p = 0.017). This evidence concerns the gene EPHA3 and metastatic malignant neoplasm in the lymph nodes.