TMPRSS2 and posterior cortical atrophy: The first identified, and most prevalent genetic irregularities, occurring in ~50% of PCa patients, involves inter- or intrachromosomal rearrangements that result in fusion of the androgen receptor (AR) DNA response element of transmembrane protease serine 2 (TMPRSS2) to variable open reading frames of the ETS family member, ETS-related gene ERG [3].