It is also reported to play an important role in migration, invasion, GSC survival and chemoradiotherapy by its ability to activate various important oncogenes, including IL-6, IGFBP-2 and c-myc, all of which are known regulators of migration capacity, glioma stem-like cells and are associated with tumor aggressiveness [49–51]. This evidence concerns the gene IGFBP2 and central nervous system cancer.