Our study showed that patients with NB were more likely to display unfavorable prognostic factors when compared with GNB patients, while in the comparison of patients with confirmed GNBi and patients with GNBn, GNBi patients more frequently demonstrated favorable factors, as most GNBi tumors were localized and no MYCN amplification was found in GNBi patients. This evidence concerns the gene MYCN and neuroblastoma.