A reprogramming cocktail incorporating SOX2, OLIG2, and POU3F2 has been used to reinstate tumorigenicity in “differentiated” glioblastoma cells (Suvà et al. 2014), and this network was generated by focusing on TFs differentially expressed between GBM stem cells and serum-induced differentiating progeny. Here, OLIG2 is linked to glioblastoma.