FOXG1 and glioblastoma: Recently, Liu et al. (2015) demonstrated that the oncogenic EGFR truncation (EGFRvIII)—found in a significant proportion of “classical” subtype GBMs—operates in part by triggering expression of FOXG1. FOXG1 protein has been shown previously to operate by attenuating the cytostatic effects of TGF-β signaling by binding and sequestration of FOXO/SMAD complexes in established glioblastoma cell lines (Seoane et al. 2004).