Ethmoid sinus mucosa of CRSwNP patients showed significantly increased expression of interleukin (IL)-5, eosinophil-cationic protein, immunoglobulin E (IgE), and Staphylococcus enterotoxin (SAE)-IgE compared with chronic rhinosinusitis without nasal polyp (CRSsNP) patients [5, 6]. This evidence concerns the gene IGHE and chronic rhinosinusitis.