Overexpression of EGFR family which has been found in many human malignancies such as gastric, Non-Small Cell Lung Cancer (NSCLC), Squamous Cell Carcinoma of the Head and Neck (SCCHN), breast, ovarian, prostate, colorectal, esophageal, bladder and renal cancers result in tumor recurrence which decreases patient survival [6, 7]. The gene discussed is EGFR; the disease is head and neck squamous cell carcinoma.